Neurobiology of Disease -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1
نویسندگان
چکیده
Judit España,1,2,3 Jorge Valero,1,2,3* Alfredo J. Miñano-Molina,1,2,3* Roser Masgrau,1,2 Elsa Martín,1,2,3 Cristina Guardia-Laguarta,3,4 Alberto Lleó,3,4 Lydia Giménez-Llort,1,5 José Rodríguez-Alvarez,1,2,3 and Carlos A. Saura1,2,3 1Institut de Neurociències, 2Departament de Bioquímica i Biologia Molecular, 3Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), 4Hospital de la Santa Creu i Sant Pau, and 5Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain 08193
منابع مشابه
Activity-Dependent Transport of the Transcriptional Coactivator CRTC1 from Synapse to Nucleus
Long-lasting changes in synaptic efficacy, such as those underlying long-term memory, require transcription. Activity-dependent transport of synaptically localized transcriptional regulators provides a direct means of coupling synaptic stimulation with changes in transcription. The CREB-regulated transcriptional coactivator (CRTC1), which is required for long-term hippocampal plasticity, binds ...
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CREB is a pivotal mediator of activity-regulated gene transcription that underlies memory formation and allocation. The contribution of a key CREB cofactor, CREB-regulated transcription coactivator 1 (CRTC1), has, however, remained elusive. Here we show that several constitutive kinase pathways and an activity-regulated phosphatase, calcineurin, converge to determine the nucleocytoplasmic shutt...
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Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and ...
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Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target genes. Here we investigate the long-distance retrograde transport of CRTC1 in hippocampal neurons. W...
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